Acetyl-CoA Carboxylase alpha antibody (AA 2223-2346)

Catalog No. ABIN5701229

The Rabbit Polyclonal anti-Acetyl-CoA Carboxylase alpha antibody has been validated for WB, IHC, ELISA, IP and IF. It is suitable to detect Acetyl-CoA Carboxylase alpha in samples from Human, Mouse and Rat.

Quick Overview for Acetyl-CoA Carboxylase alpha antibody (AA 2223-2346) (ABIN5701229)

Target: Acetyl-CoA Carboxylase alpha (ACACA)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Acetyl-CoA Carboxylase alpha antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Product Details anti-Acetyl-CoA Carboxylase alpha Antibody

Binding Specificity: AA 2223-2346

Purpose: ACACA antibody

Immunogen:

Immunogen sequence: 2223-2346aa

Immunogen: acetyl-Coenzyme A carboxylase alpha

Isotype: IgG

Application Details

Application Notes: WB :1:200-1:2000,IHC:1:20-1:200,IF:1:20-1:200,IP:1:200-1:2000

Comment:

HeLa cells were subjected to SDS PAGE followed by western blot with FNab00077(ACACA antibody) at dilution of 1:500

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for Acetyl-CoA Carboxylase alpha

Target: Acetyl-CoA Carboxylase alpha (ACACA)

Alternative Name: ACACA

Background:

Synonyms: Acetyl-CoA carboxylase 1 (ACC1)|Acetyl-Coenzyme A carboxylase alpha (ACC-alpha)|ACACA|ACAC|ACC1|ACCA

Background: ACACA(Acetyl-CoA carboxylase 1, ACC), also named as ACAC, ACC1 and ACCA, belongs to the biotin containing enzyme family. It catalyzes the synthesis of malonyl-CoA, which is an intermediate substrate playing a pivotal role in the regulation of fatty acid metabolism and energy production. ACACA is involved in the biosynthesis of fatty acids, and malonyl-CoA produced is used as a building block to extend the chain length of fatty acids by fatty acid synthase(FAS)(PMID:19900410). It has 4 isoforms produced by alternative promoter usage with the molecular weight between 260 kDa and 270 kDa.

Molecular Weight: 270kDa

UniProt: Q13085

Pathways: AMPK Signaling, Ribonucleoside Biosynthetic Process, Warburg Effect